Pigs with bipolar electrodes implanted on the antrum and duodenum were exposed to heat-labile enterotoxin from E. coli (LT) infused intraduodenally. The exposure was repeated after three days of supplementing feed with α-ketoglutarate (AKG). 0.5 µg/kg of LT induced prolonged changes in the migrating myoelectric complex (MMC) without inducing clinical signs of enterotoxaemia. AKG had no effect on the basic MMC pattern, but prevented LT-induced changes. The possible mechanism of AKG and LT-induced alteration may involve gamma-aminobutyric acid (GABA) synthesis and activation of GABAergic neurotransmission in the gut.