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ORIGINAL PAPER
Antidiabetic effect of black pepper, turmeric, and ajwa date pulp,
seed, and their mixtures as antioxidants in alloxan diabetic rats
1
University of Agriculture Faisalabad, Department of Zoology, Wildlife and Fisheries, Sub Campus Toba Tek Singh, 36050, Pakistan
2
University of Agriculture Faisalabad, Institute of Physiology and Pharmacology, Faisalabad 38000, Pakistan
3
University of Okara, Department of Chemistry, Okara 56300, Punjab, Pakistan
4
The Islamia University of Bahawalpur, Department of Agronomy, Faculty of Agriculture and Environment, Bahawalpur 63100, Pakistan
5
The Islamia University of Bahawalpur, Department of Eastern Medicine, Faculty of Medicine and Allied Health Sciences,
Bahawalpur 63100, Pakistan
6
University of Tabuk, Alwajh College, Department of Chemistry, Tabuk 71491, Saudi Arabia
7
University of Tabuk, Department of Biochemistry, College of Science, Tabuk 71491, Saudi Arabia
8
Jazan University, Department of Clinical Nutrition, Applied Medical Science, Jazan 45142, Saudi Arabia
9
Helwan University, College of Home Economic, Food and Science Department, Cairo 11795 Egypt
10
King Abdul Aziz University, Faculty of Human Sciences and Design, Department of Food and Nutrition,
P.O. Box 42807, Jeddah 21551, Saudi Arabia
11
King Saud bin Abdulaziz University for Health Sciences, College of Applied Medical Sciences, Clinical Nutrition Department,
P.O. Box 2477, Al Ahsa 31982, Saudi Arabia
12
King Saud bin Abdulaziz University for Health Sciences, Department of Pediatrics, College of Medicine, Riyadh, Saudi Arabia
13
University of Tabuk, Department of Food Science and Nutrition, Faculty of Science, Tabuk 71491, Saudi Arabia
14
Shaheed Benazir Bhutto University Sheringal, Department of Environmental Sciences, Dir (U), Khyber Pakhtunkhwa 18000, Pakistan
15
The University of Western Australia, School of Biological Sciences, 35 Stirling Highway, Perth, WA 6009, Australia
Publication date: 2023-09-04
Corresponding author
M. Sarfraz
University of Agriculture Faisalabad, Department of Zoology, Wildlife and Fisheries, Sub Campus Toba Tek Singh, 36050, Pakistan
University of Agriculture Faisalabad, Department of Zoology, Wildlife and Fisheries, Sub Campus Toba Tek Singh, 36050, Pakistan
A. Ditta
Shaheed Benazir Bhutto University Sheringal, Department of Environmental Sciences, Dir (U), Khyber Pakhtunkhwa 18000, Pakistan
Shaheed Benazir Bhutto University Sheringal, Department of Environmental Sciences, Dir (U), Khyber Pakhtunkhwa 18000, Pakistan
J. Anim. Feed Sci. 2024;33(1):28-46
KEYWORDS
TOPICS
ABSTRACT
Testing natural antihyperlipidemic substances is necessary due
to the increasing prevalence of diabetes mellitus, which leads to chronic hyperglycaemia
and poses a significant threat to public health and well-being
worldwide. The present study investigated the anti-diabetic effect of black pepper,
turmeric, and ajwa date pulp + seed and their mixtures as hypolipidemic,
antioxidant and protective agents on the liver and kidney by examining histological
changes in alloxanised diabetic rats. Eleven groups consisting of eighteen
males and eighteen females were divided into a normal control (nondiabetic),
a positive control (diabetic), positive groups receiving glibenclamide
(10 mg kg-1 body weight), black pepper (BP), turmeric (T), ajwa pulp (AP), ajwa
seeds (AS) aqueous extracts and their various combinations. The dose of BP aqueous
extract was 50 mg kg-1 body weight, while the dose of the other materials was
500 mg kg-1 body weight. The aqueous extracts were administered orally once
daily for eight weeks. Our phytochemical screening detected the presence of flavonoids,
tannins, saponins, steroids, and alkaloids in these extracts. The results
pertaining to serum levels of glucose, lipids, glycosylated haemoglobin, and antioxidant
biomarkers revealed significant improvements after administration of AS,
BP + AS, and the mixture of all extracts. Moreover, histological analyses demonstrated
the protective effects of these extracts. In conclusion, all tested materials,
especially ajwa seeds administered alone and in combination with black pepper
extract, exerted significant antihyperlipidemic and weight-stabilising effects in
alloxanised diabetic rats. Therefore, these natural substances hold promise as
potential herbal medicines for managing diabetes mellitus.
CONFLICT OF INTEREST
The Authors declare that there is no conflict of
interest.
REFERENCES (83)
1.
Abdessalem M., Hamza H., Guillermo R., Ana J., Marianne S., 2019. Date palm fruits as a potential source of functional dietary fiber: A Review. Food Sci Technol Res. 25, 1–10, https://doi.org/10.3136/fstr.2....
2.
Ahmad N.H., Fazal B.H., Abbasi M., Rashid T., Fatima N., 2010. Efficient regeneration and antioxidant potential in regenerated tissues of Piper nigrum L. Plant Cell Tissue Organ Cult. 102, 129–134, https://doi.org/10.1007/s11240....
3.
Akasha I.A., Campbell L., Euston S.R., 2012. Extraction and characterization of protein fraction from date palm fruit. World Acad. Sci. Eng. Technol. 70, 292–294, https://doi.org/10.5281/zenodo....
4.
Al-Dashti Y.A., Holt R.R., Keen C.L., Hackman R.M., 2021. Date Palm Fruit (Phoenix dactylifera): effects on vascular health and future research directions. Int. J. Mol. Sci. 22, 9, 4665, https://doi.org/10.3390/ijms22....
5.
Alezandro M.R., Granato D., Genovese M.I., 2013. Jaboticaba (Myrciaria jaboticaba (Vell.) Berg), a Brazilian grape-like fruit, improves plasma lipid profile in streptozotocin-mediated oxidative stress in diabetic rats. Food Res. Int. 54, 650–659, https://doi.org/10.1016/j.food....
6.
Al-Farsi M.A., Lee C.Y., 2008. Optimization of phenolics and dietary fire extraction from date seeds. Food Chem. 108, 977–985, https://doi.org/10.1016/j.food....
7.
Al-Jasass F.M., Siddiq M., Sogi D.S., 2015. Antioxidants activity and color evaluation of date fruit of selected cultivars commercially available in the United States. Adv. Chem. 5. http://dx.doi.org/10.1155/2015....
8.
Almdal T.P., Heindorff H., Bardram L., Vilstrup H., 1990. Increased amino acid clearance and urea synthesis in a patient with glucagonoma. Gut. 31, 946–948, https://doi.org/10.1136/gut.31....
9.
ALtamimi J.Z., AlFaris N.A., Al-Farga A., Alshammari G.M., BinMowyna M.N., Yahya, M.A., 2021. Curcumin reverses diabetic nephropathy in streptozotocin-induced diabetes in rats by inhibition of PKCβ/p66Shc axis and activation of FOXO- 3a. J. Nutr. Biochem. 87, 108515, https://doi.org/10.1016/j.jnut....
10.
AOAC, 1990. Association of Official Analytical Chemists. 15th Ed. Arlington (VA), USA.
11.
Assirey E.A.R., 2015. Nutritional composition of fruit of 10 date palm (Phoenix dactylifera L.) cultivars grown in Saudi Arabia. J. Taibah Univ. Sci. 9, 75–79, https://doi.org/10.1016/j.jtus....
12.
Aziz N., Wal A., Wal P., Pal R.S., 2019. Preparation and evaluation of the polyherbal powder: The Nature’s Pharmacy for the Treatment of Diabetes Mellitus and Its Complications. Pharmacophores. 10(1), 60–70, https://pharmacophorejournal.c....
13.
Baliga M.S., Baliga B.R.V., Kandathil S.M., Bhat H.P., Vayalil P.K., 2011. A review of the chemistry and pharmacology of the date fruits (Phoenix dactylifera L.). Food Res. Int. 44, 7, 1812–1822, https://doi.org/10.1016/j.food....
14.
Bancroft J.D., Gamble, M., 2007. Theory and practice of histological techniques. Churchill Livingstone, Philadelphia, pp. 131–133.
15.
Boots A.W., Haenen G.R., Bast A., 2008. Health effects of quercetin: from antioxidant to nutraceutical. Eur. J. Pharmacol. 585, 325–337, https://doi.org/10.1016/j.ejph....
16.
Butler A.E., Obaid J., Wasif P., Varghese J.V., Abdulrahman R., Alromaihi D., Atkin S.L., Alamuddin, N., 2022. Effect of date fruit consumption on the glycemic control of patients with type 2 diabetes: A randomized clinical trial. Nutrients. 14, 3491, https://doi.org/10.3390/nu1417....
17.
Chinma C.E., Igyor M.A., 2007. Micronutrients and anti-nutritional contents of selected tropical vegetables grown in SouthEast, Nigeria. Niger. Food J. 25, 111–116, https://doi.org/10.4314/nifoj.....
18.
Corcoran R.M., Durnan S.M., 1977. Albumin determination by a modified bromcresol green method. Clin. Chem. 23, 765–766, https://pubmed.ncbi.nlm.nih.go....
19.
De Melo I.S.V., Dos Santos A.F., Bueno N.B., 2018. Curcumin or combined curcuminoids are effective in lowering the fasting blood glucose concentrations of individuals with dysglycemia: Systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 128, 137–144, https://doi.org/10.1016/j.phrs....
20.
El Fouhil A.F., Ahmed A.M., Darwish H.H., Atteya M., Al-Roalle A.H., 2011. An extract from date seeds having a hypoglycemic effect. Is it safe to use? Saudi Med. J. 32, 791–796, https://pubmed.ncbi.nlm.nih.go....
21.
El-Demerdash F.M., Yousef M.I., El-Naga N.I., 2005. Biochemical study on the hypoglycemic effects of onion and garlic in diabetic rats. Food Chem. Toxicol. 43, 57–63, https://doi.org/10.1016/j.fct.....
22.
Ganong W.F., 2000. Circumventricular organs: definition and role in the regulation of endocrine and autonomic function. Clin. Exp. Pharmacol. Physiol. 27, 422–427, https://doi.org/10.1046/j.1440....
23.
Gornall A.G., Bardawill C.J., David M.M., 1949. Determination of serum proteins by means of the biuret reaction. J. Biol. Chem. 177, 751–66, https://doi.org/10.1016/S0021-...
24.
Hadrami A., Al-Khayri J., 2012. Socioeconomic and traditional importance of date palm. Emir. J. Food Agric. 24, 371–385, https://www.researchgate.net/p....
25.
Halaby M.S., Farag M.H., Gerges A.H., 2014. Potential effect of date pits fortified bread on diabetic rats. Int. J. Food Sci. Nut. 3, 49–59, https://doi.org/10.11648/j.ijn....
26.
He G., Aoyama Y., 2003. Effects of adding some dietary fibers to a cystine diet on the activities of liver antioxidant enzymes and serum enzymes in rats. Biosci. Biotechnol. Biochem. 67, 617–621, https://doi.org/10.1271/bbb.67....
27.
Hinkaew J., Aursalung A., Sahasakul Y., Tangsuphoom N., Suttisansanee U., 2021. A comparison of the nutritional and biochemical quality of date palm fruits obtained using different planting techniques. Molecules 26, 2245, https://doi.org/10.3390/molecu....
28.
Hua Y., Sun J.Y., Su Y., Qu Q., Wang H.Y., Sun W., Kong X.Q., 2021. The safety and efficacy of rivaroxaban compared with warfarinin patients with atrial fibrillation and diabetes: a systematic review and meta-analysis. Am J Cardiovasc Drugs. 21, 51–61, https://doi.org/10.1007/s40256....
29.
Huang W., Zhang H., Li C., 2012. Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing. J. Zhejiang Univ. Sci. 13, 94–102, https://doi.org/10.1631/jzus.B....
30.
Hursel R., Westerterp-Plantenga M.S., 2010. Thermogenic ingredients and body weight regulation. Int. J. Obes. 34, 659–669, https://doi.org/10.1038/ijo.20....
31.
Johnson O.R., Elizabeth M.A., Oloruntoba A.C., Sunday A.I., 2012. Effects of pre-induction administration of Allium sativum on some biochemical parameters in alloxan-induced diabetic rats. Res. J. Appl. Sci. Eng. Tech. 4, 5129–5135, https://www.semanticscholar.or....
32.
Juretic D., Motejlkova A., Kunovic B, Vujic L., Mesic R., Siemeon-Rodolf V., 2006. Paraoxonase/arylesterase in serum of patients with type ll diabetes mellitus. Acta Pharm. 56, 59–68, https://pubmed.ncbi.nlm.nih.go....
33.
Kadam P.V., Yadav K.N., Patel F.A., Karjikar F.A., Patil M.J., 2013. Pharmacognostic, phytochemical, and physicochemical studies of piper nigrum Linn. Fruit (Piperaceae). Int. Res. J. Pharm. 4, 5, https://doi.org/10.7897/2230-8....
34.
Kalpravidh R.W., Siritanaratkul N., Insain P., Charoensakdi R., Panichkul N., Hatairaktham S., Srichairatanakool S., Phisalaphong C., Rachmilewitz E., Fucharoen S., 2010. Improvement in oxidative stress and antioxidant parameters in β-thalassemia/Hb E patients treated with curcuminoids. Clin. Biochem. 43, 424–429, https://doi.org/10.1016/j.clin....
35.
Khaliq T., Sarfraz M., Ashraf, M.A., 2015. Recent progress for the utilization of Curcuma longa, Piper nigrum, and Phoenix dactylifera seeds against type 2 diabetes. West Indian Med J. 34, 5, 527–532, https://doi.org/10.7727/wimj.2....
36.
Larcan A., Lambert H., Laprevote-Heully M.C., Delorme N., 1979. Light and electron microscopic study of hepatic lesions in the course of hyperlactatemia in diabetic patients. Diab. Metabol. 5, 103–112, https://pubmed.ncbi.nlm.nih.go....
37.
Lin J.K., Lin-Shiau S.Y., 2006. Mechanisms of hypolipidemic and anti-obesity effects of tea and green tea polyphenols. Mol. Nutr. Food Res. 50, 211–217, https://doi.org/10.1002/mnfr.2....
38.
Liu Y., Wang Q., Wu K., Sun Z., Tang Z., Li X., Zhang B., 2022. Anthocyanins’ effects on diabetes mellitus and islet transplantation. Crit. Rev. Food Sci. Nutr. https://doi.org/10.1080/104083....
39.
Luo Y., Dong X., Lu S., Gao Y., Sun G., Sun X., 2021. Gypenoside XVII alleviates early diabetic retinopathy by regulating Müller cell apoptosis and autophagy in db/db mice. Eur. J. Pharmacol. 895, 173893, https://doi.org/10.1016/j.ejph....
40.
Ma C.X., Ma X.N., Guan C.H., Li Y.D., Mauricio D., Fu S.B., 2022. Cardiovascular disease in type 2 diabetes mellitus: progress toward personalized management. Cardiovasc. Diabetol. 21, 74, https://doi.org/10.1186/s12933....
41.
Madkor H.R., Mansour S.W., Ramadan G., 2011. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycemia, dyslipidemia, and oxidative stress in streptozotocin–nicotinamide diabetic rats. British J. Nut. 105, 1210–1217, https://doi.org/10.1017/S00071....
42.
Marton L.T, Pescinini-E-Salzedas L.M., Camargo M.E.C., Barbalho S.M., Haber J.F.D.S., Sinatora R.V., Detregiachi C.R.P., Girio R.J.S., Buchaim D.V., Cincotto dos Santos Bueno P., 2021. The Effects of curcumin on diabetes mellitus: A Systematic Review. Front Endocrinol. 12, 669448, https://doi.org/10.3389/fendo.....
43.
Mia M.A.T., Mosaib M.G., Khalil M.I., Islam M.A., Gan S.H., 2020. Potentials and safety of date palm fruit against diabetes: A critical review. Foods. 9, 1557, https://doi.org/10.3390/foods9....
44.
Mosenzon O. et al, 2021. CAPTURE: a multinational, cross-sectional study of cardiovascular disease prevalence in adults with type 2 diabetes across 13 countries. Cardiovasc Diabetol. 20, 154, https://doi.org/10.1186/s12933....
45.
Najafi M., 2011. Date seeds: A novel and inexpensive source of dietary fiber. Int. Conference Food Eng. Biotechnol. 9, 323-326, Corpus ID: 29235027.
46.
Nandhagopal K., Kanniyakumari M., Anbu J., Velpandian V., 2013. Antidiabetic activity of Karchure chooranam on alloxaninduced diabetic rats. Int. J. Pharm. Bio. Sci. 4, 434–439, https://www.researchgate.net/p....
47.
Navarro C.M., Montilla P.M., Martin A., Jimenez J., Utrill, P.M., 1993. Free radicals scavenger and antihepatotoxic activity of Rosmarinus tomentosus. Plant Med. 59, 312–314, https://doi.org/10.1055/s-2006....
48.
Nehdi I., Omri S., Khalil M.I., Al–Resayes S.I., 2010. Characteristics and chemical composition of date palm (Phoenix canariensis) seeds and seed oil. Ind. Crop. Prod. 32, 360–365, https://doi.org/10.1016/j.indc....
49.
Niewiadomska J., Gajek-Marecka A., Gajek J., Noszczyk-Nowak A., 2022. Biological potential of polyphenols in the context of metabolic syndrome: An analysis of studies on animal models. Biology 11, 559, https://doi.org/10.3390/biolog....
50.
Nwofia G.E., Kelechukwu C., Nwofia B.K., 2013. Nutritional composition of some Piper nigrum (L) accessions from Nigeria. Int. J. Med. Arom. Plants. 3, 247–254, https://www.scinapse.io/papers....
51.
Park U.H., Jeong H.S., Jo E.Y., Park T., Yoon S.K., Kim E.J., Jeong J.C., Um S.J., 2012. Piperine, a component of black pepper, inhibits adipogenesis by antagonizing PPARγ activity in 3T3- L1 cells. J. Agric. Food Chem. 60, 3853–3860, https://doi.org/10.1021/jf2045....
52.
Patergnani S., Bouhamida E., Leo S., Pinton P., Rimessi A., 2021. Mitochondrial oxidative stress and “mito-inflammation”: actors in the diseases. Biomedicines. 9, 216, https://doi.org/10.3390/biomed....
53.
Pivari F., Mingione A., Brasacchio C., Soldati L., 2019. Curcumin and type 2 diabetes mellitus: prevention and treatment. Nutrients. 11, 1837, https://doi.org/10.3390/nu1108....
54.
Platat C., Habib H.M., AL Maqbali F.D., Jaber N.N., Ibrahim W.H., 2014. Identification of date seed varieties patterns to optimize the nutritional benefits of date seeds. J. Nutr. Food Sci. 8, 8, https://doi.org/10.4172/2155-9....
55.
Ragab A.R., Elkablawy M.A., Sheik B.Y., Baraka H.N., 2013. Antioxidant and tissue-protective studies on ajwa extract: dates from Al Madinah Al-Monwarah, Saudia Arabia. J. Environ. Anal. Toxicol. 3, 163, https://doi.org/10.12816/00050....
56.
Rivera-Mancía S., Trujillo J., Chaverri J.P., 2018. Utility of curcumin for the treatment of diabetes mellitus: evidence from preclinical and clinical studies. J. Nutrit. Intermed. Metabol. 14, 29–41, https://doi.org/10.1016/j.jnim....
57.
Robinson M.L., Brown B., Williams C.F., 2012. The date palm in southern Nevada. University of Nevada cooperative extension, http://www.unce.unr.edu/public... /sp0212.pdf.
58.
Salih D.H., 2013. Study of liver function tests and renal function tests in diabetic type II patients. IOSR J. Appl. Chem. 3, 42–44, https://doi.org/10.9790/5736-0....
59.
Sarfraz M., 2020. Diabetes mellitus and protective approaches of medicinal plants: Present status and future prospects. In: M. Eddouks (Ed.), Phytotherapy in the Management of Diabetes and Hypertension, Vol. 3, 38–60, https://doi.org/10.2174/978981....
60.
Sarfraz M., Sajid S., Ashraf M.A., 2016. Prevalence and pattern of dyslipidemia in hyperglycemic patients and its associated factors among Pakistani population. Saudi J. Biol. Sci. 23, 761–766, https://doi.org/10.1016/j.sjbs....
61.
Sarfraz M., Tanweer K., Junaid A.K., Bilal A., 2017. Effects of aqueous extract of black pepper and ajwa seed on liver enzymes in alloxan-induced diabetic Wister albino rats. Saudi Pharma. J. 25, 449–452, https://doi.org/10.1016/j.jsps....
62.
Sawiress F.A.R., 2011. Effect of ginseng extract supplementation on renal functions in diabetic rats. J. Agri. Sci. 3, 17–31, https://doi.org/10.5539/jas.v3....
63.
Shabi R.R., Kumari V., 2014. Qualitative phytochemical characterization of thorn extracts of Canthium parviflorum Lam. Int. Res. J. Pharm. App. Sci. 4, 13–17.
64.
Shahwar D., Muhammad A.R., Afifa S., Madiha R., Faiza Ilyas I.C., Merva J., Sami U., Saif U., 2012. Antioxidant potential of the extracts of Putranjiva roxburghii, Conyza bonariensis, Woodfordia fruiticosa and Senecio chrysanthemoids. Afr. J. Biotechnol. 18, 4288–4295, https://doi.org/10.5897/AJB11.....
65.
Sindhu S., Manorama S., Alfamol P.M., 2013. Preliminary phytochemical analysis and antimicrobial activity of Piper longum L. (Piperaceae). Mintage J. Pharma. Med. Sci. 2, 21–23, Corpus ID: 90295006.
66.
Singh U., Singh S., Kochhar A., 2012a. Therapeutic potential of antidiabetic nutraceuticals. Phytopharmacology 2, 144–169, Corpus ID: 160016701.
67.
Singh V., Guizani N., Essa M.M., Hakkim F.L., Rahman M.S., 2012b. Comparative analysis of total phenolics, flavonoid content, and antioxidant profile of different date varieties (Phoenix dactylifera L.) from Sultanate of Oman. Int. Food Res. J. 19, 1063–1070, Corpus ID: 54178170.
68.
Snedecor G.W., Cochran W.G., 1989. Statistical Methods. 8th Edition. Ames: Iowa State Press. xix + 491 pp., https://doi.org/10.3102/107699....
69.
Sotnikova R., Nosalova V., Navarova J., 2013. Efficacy of quercetin derivatives in the prevention of ulcerative colitis in rats. Interdisciplinary Toxicol. 6, 9–12, https://doi.org/10.2478/intox-....
70.
Springfield E.P., Eagles P.K., Scott G., 2005. Quality assessment of South African herbal medicines by means of HPLC fingerprinting. J. Ethnopharmacol. 101, 75–83, https://doi.org/10.1016/j.jep.....
71.
Suresh S., Guizani N., Al-Ruzeiki M., Al-Hadhrami A., Al-Dohani H., Al-Kindi I., Rahman M.S., 2013. Thermal characteristics, chemical composition, and polyphenol contents of date-pits powder. J. Food Eng. 119, 668–679, https://doi.org/10.1016/j.jfoo....
72.
Tresina P.S., Santhiya Selvam M., Doss A., Mohan V.R., 2022. Antidiabetic bioactive natural products from medicinal plants. Stud. Nat. Prod. Chem. 75, 75–118, https://doi.org/10.1016/B978-0....
73.
Tschiersch J.E., 2012. Biologically evaluation of pan bread supplemented with vital gluten, lupin, fenugreek, and turmeric flour blends. Int. J. Agr. Env. 2, 47–59.
74.
Vasco C., Ruales J., Kamal-eldin A., 2008. Total phenolic compounds and antioxidant capacities of major fruits from Ecuador. Food Chem. 111, 816–823, https://doi.org/10.1016/j.food....
75.
WHO, 2021. World health statistics 2021: monitoring health for the SDGs, sustainable development goals, https://apps.who.int/iris/hand....
76.
Yang J., Miao X., Yang F., Cao J., Liu X., Fu J., Su G., 2021. Therapeutic potential of curcumin in diabetic retinopathy (Review). Int. J. Mol. Med. 47, 75, https://doi.org/10.3892/ijmm.2....
77.
Yao Q., Ke Z.Q., Guo S., Yang X.S., Zhang F.X., Liu X.F., Chen X., Chen H.G., Ke H.Y., Liu C., 2018. Curcumin protects against diabetic cardiomyopathy by promoting autophagy and alleviating apoptosis. J. Mol. Cell Cardiol. 124, 26–34, https://doi.org/10.1016/j.yjmc....
78.
Yuzefovych L.V., Pastukh V.M., Ruchko M.V., Simmons J.D., Richards W.O., Rachek L.I., 2019. Plasma mitochondrial DNA is elevated in obese type 2 diabetes mellitus patients and correlates positively with insulin resistance. PLoS ONE. 14, e0222278, https://doi.org/10.1371/journa....
79.
Zein N., Constantinos S., Suwimol C., 2020. Utilization of date byproducts in the food industry. Emir. J. Food Agric. 32, 808–815, https://doi.org/10.9755/ejfa.2....
80.
Zhang P., Fang J., Zhang J., Ding S., Gan D., 2020. Curcumin inhibited podocyte cell apoptosis and accelerated cell autophagy in diabetic nephropathy via regulating beclin1/UVRAG/Bcl2. Diabetes Metab. Syndr. Obes. 13, 641–652, https://doi.org/10.2147/DMSO.S....
81.
Zhang P., Sun X., Jin H., Zhang F.L., Guo Z.N., Yang Y., 2019. Association between obesity type and common vascular and metabolic diseases: A cross-sectional study. Front. Endocrinol. 10, 900, https://doi.org/10.3389/fendo.....
82.
Ziamajidia N., Nasiria A., Abbasalipourkabira R., Moheb S.S., 2017. Effects of garlic extract on TNF-a expression and oxidative stress status in the kidneys of rats with STZ + nicotinamideinduced diabetes. Pharm. Biol. 55, 526–53, https://doi.org/10.1080/138802....
83.
Zu Y., Li C., Fu Y., Zhao C., 2006. Simultaneous determination of catechin, rutin, quercetin, kaempferol, and isorhamnetin in the extract of sea buckthorn (Hippophae rhamnoides L.) leaves by RP-HPLC with DAD. J. Pharm. Biomed. Anal. 41, 714–719, https://doi.org/10.1016/j.jpba....
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