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ORIGINAL PAPER
Effect of caffeine on adenosine and ryanodine receptor
gene expression in the hypothalamus, pituitary, and choroid
plexus in ewes under basal and LPS challenge conditions
1
Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10-748 Olsztyn, Poland
2
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
Publication date: 2022-12-20
Corresponding author
A. P. Herman
The Kielanowski Institue of Animal Physiology and Nutrition, Polish Academy of Sciences
The Kielanowski Institue of Animal Physiology and Nutrition, Polish Academy of Sciences
J. Anim. Feed Sci. 2023;32(1):17-25
KEYWORDS
TOPICS
ABSTRACT
Caffeine is a plant alkaloid that stimulates the central nervous
system. It easily crosses the blood-brain barrier located in the endothelial cells
of brain microvessels and the blood-cerebrospinal fluid barrier located in the
epithelial cells of the choroid plexus (ChP). Caffeine exerts most of its biological
effects by antagonising adenosine receptors (ADORs), but is also an agonist of
ryanodine receptors (RYRs). A recent study in a sheep model has suggested
that the effect of caffeine on the expression of many genes may depend on the
animal’s immune status. Therefore, the aim of the study was to determine the
effect of caffeine administration (iv, 30 mg/kg) in ewes, under basal and acute
inflammatory conditions induced by lipopolysaccharide injection (iv, 400 ng/kg),
on the expression of ADOR and RYR genes in the mediobasal hypothalamus
(MBH), anterior pituitary (AP), and ChP. Our study showed that among caffeineinteracting
receptors, ADORA1 was the most highly expressed in the AP and
ChP, while ADORA3 in the MBH. Caffeine reduced (P < 0.05) the inhibitory
effect of inflammation on ADORA1, but only in the MBH, and decreased
(P < 0.05) the stimulatory effect of endotoxin treatment on ADORA2B in the MBH
and ChP. In contrast to ADORs, the expression of RYRs was less sensitive to
the effects of inflammation and caffeine. We showed that caffeine influenced the
expression of its receptor genes in the brain, but this effect seemed to be tissuedependent
and could be affected by the immune status of the animals. However,
the physiological implications of these results require further detailed studies.
FUNDING
This work was supported by funds granted by the
National Science Centre, Poland, based on Decision
No. DEC-2017/25/B/NZ9/00225. AS and JS were
supported by statutory research funds of the Institute
of Animal Reproduction and Food Research.
CONFLICT OF INTEREST
The Authors declare that there is no conflict of
interest.
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