REVIEW PAPER
Effect of high doses of L-ascorbic acid on the
antioxidative/oxidative state in the rats
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1
Warsaw Agricultural University,
Department of Animal Nutrition and Feed Science,
Ciszewskiego 8, 02-786 Warszawa, Poland
2
The Royal Veterinary and Agricultural University,
Department of Animal and Veterinary Basic Sciences,
Bülowsvej 13, Frederiksberg C, Denmark
Publication date: 2005-06-26
Corresponding author
T. Niemiec
Warsaw Agricultural University,
Department of Animal Nutrition and Feed Science,
Ciszewskiego 8, 02-786 Warszawa, Poland
J. Anim. Feed Sci. 2005;14(Suppl. 1):553-556
KEYWORDS
ABSTRACT
The objective of this study was to determine the effects of mega-doses of vitamin C (0.3, 0.6 and
0.9% of diet) as a dietary supplement for rats on selected indices of the antioxidative/oxidative state
in 40 growing Wistar rats (4 × 10). It was found that L-ascorbic acid and Total Antioxidative State
(TAS) in plasma did not increase with increasing vitamin C supply. The results indicate that high
doses of L-ascorbic acid (0.3 and 0.9 but not 0.6%) increased the concentration of this antioxidant
in plasma. Supplementation of vitamin C above 0.3% to the diets had pro-oxidative effects on lipid
structures, while application of 0.9% promoted oxidative degradation of rat livers.
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