The objective of this study was to evaluate the effects of a multi-enzyme complex containing xylanase, amylase, and protease (XAP) on growth performance, apparent digestibility, blood profile, intestinal villus height, and faecal gas emission in weaning pigs. One hundred and twenty-eight piglets [(Yorkshire × Landrace) × Duroc] were used in a two-phase feeding trial: phase I (days 1 to 14) and phase II (days 15 to 42). Piglets were randomly allotted to two treatments, one 100 mg/kg XAP (xylanases, 2000 U/kg diet; amylases, 200 U/kg diet; proteases, 2000 U/kg diet) and one without, with 16 replicates (two barrows and two gilts) per pen. In phase II, the XAP group showed increased average daily gain (ADG) (P < 0.05) compared to the control group. At the end of the feeding trial, piglets supplemented with XAP showed enhanced ADG and gain-to-feed ratio (P < 0.05). Moreover, pigs fed the XAP diet had a higher (P < 0.05) duodenal and jejunal villus height compared to the control group. There were no significant differences in other parameters. The inclusion of 100 mg/kg XAP in maize-soybean meal-based diets improved growth performance and intestinal villus height in piglets, suggesting its potential benefits for the growth and gut health of these animals.