ORIGINAL PAPER
Effects of feed supplemented with selenite
or Se-yeast on antioxidant enzyme activities
in lamb tissues
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1
University of Veterinary Medicine,
041 81 Košice, Slovak Republic
2
Institute of Animal Physiology, Slovak Academy of Sciences,
040 01 Košice, Slovak Republic
Publication date: 2006-11-06
Corresponding author
A. Sobeková
University of Veterinary Medicine,
041 81 Košice, Slovak Republic
J. Anim. Feed Sci. 2006;15(4):569-577
KEYWORDS
ABSTRACT
The activities of antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione
peroxidase (GSHPx), glutathione-S-transferase (GST) and glutathione reductase (GR) were examined
in liver, kidney cortex and heart tissues of lambs fed diets supplemented with inorganic (sodium
selenite) and an organic (Se-yeast) form of selenium. Additional selenium resulted in a significant
increase of the Se content in the examined tissues in both supplemented groups. The activities of
GSHPx, CAT in the liver as well as of CAT, GST and SOD in the kidney cortex were significantly
lower in the Se-yeast supplemented group when compared with both the control and selenite-fed
groups. In the heart, the activities of all of the assayed enzymes increased in both supplemented
groups. SOD activity was found to be significantly higher in the Se-yeast supplemented group when
compared with the selenite group. In addition, two Cu, Zn-SOD isoenzymes of higher band intensity
were generated in this group, probably as a result of oxidative stress, which was also manifested
by a significant increase of thiobarbituric acid reactive substances (TBARS). The presented results
suggest specific regulation of antioxidant enzyme activities in the tissues of lambs depending on the
form of selenium intake.
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