ORIGINAL PAPER
Growth hormone gene polymorphism in chicken
divergently selected for axial skeleton malformation
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Department of Molecular Cytogenetics,
Institute of Genetics and Animal Breeding,
Polish Academy of Sciences,
Jastrzębiec, 05-552 Wólka Kosowska, Poland
Publication date: 2005-08-04
Corresponding author
B. Wardęcka
Department of Molecular Cytogenetics,
Institute of Genetics and Animal Breeding,
Polish Academy of Sciences,
Jastrzębiec, 05-552 Wólka Kosowska, Poland
J. Anim. Feed Sci. 2005;14(3):561-570
KEYWORDS
ABSTRACT
Chicken growth hormone (cGH), a polypeptyde hormone synthesized in and secreted by pituitary
gland, is involved in a variety of physiological functions such as growth, body composition, egg
production, aging and reproduction. Two breeds of chickens selected for high and low incidence of
scoliosis, were analysed for polymorphisms in the growth hormone gene (GH). The polymorphism
of GH gene (PCR-RFLP) was analysed in 30 chickens each breed, Rhode Island Red and Sussex.
It was observed five RFLPs in GH gene, three at MspI sites in the intron 1 of cGH gene and two
MspI sites in the intron 4 of cGH gene. The selection for axial skeleton malformation appears to
have affected the frequency of GH alleles. It was found differences in allelic distribution between
the affected (H) and unaffected (L) lines. Whereas none of the alleles was observed as specific to
H or L lines for both breeds. The experimental material examined constitutes a valuable source for
identification of real genes causing skeletal defects.
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