REVIEW PAPER
How yeast cell wall components can alleviate
mycotoxicosis in animal production and improve
the safety of edible animal products
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1
INRA, URH-DIMA, Research Centre of Clermont-Theix,
63122 St. Genes Champanelle, France
2
Alltech-France, 2-4 avenue du 6 juin 1944, 95190 Goussainville, France
Publication date: 2005-06-21
Corresponding author
J.-P. Jouany
INRA, URH-DIMA, Research Centre of Clermont-Theix,
63122 St. Genes Champanelle, France
J. Anim. Feed Sci. 2005;14(Suppl. 1):171-190
KEYWORDS
ABSTRACT
Several authors have reported that the addition of yeast cell walls to contaminated feeds
alleviates the harmful effects of mycotoxins, but nothing is known on the chemical interactions
between the binder and the toxins.
We showed that β-D-glucans are the yeast component responsible for the complexation of
mycotoxins, and that the reticular organization of β-D-glucans and the distribution between β-(1,3)-
D-glucans and β-(1,6)-D-glucans play a major role in the efficacy. Weak hydrogen and van der
Waals bonds are involved in the complexation of mycotoxins by β-D-glucans, thus indicating that
the chemical interaction is more of “adsorption type” than “binding type”. We performed molecular
modelling and calculated potential energy to estimate the stability of the complexes.
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