The frequencies of spontaneous and in vitro mutagen-induced unstable chromosomal lesions
were compared in the groups of subfertile cows, ewes and sows (test groups) as well as the animals
without any reproductive disturbances (control groups). The mean percentage of 5-azacytidine- and bromodeoxyuridine-induced defects differed statistically between the test and control groups
(P≤0.01 in cattle, P≤0.05 in sheep and pigs). In the groups of animals with reproductive problems the
number of defects observed in some chromosomes exceeded the expected values (calculated according to the relative chromosome length), but only in the case of X chromosome differed at the level of
statistical significance. Moreover, the groups of cows analysed differed significantly as regards the
number of chromatid breaks/gaps at the Xq2.4 and Xq3.1 fragile sites. The excessive chromosome
instability in subfertile farm animals, particularly the X-specific loci, may result in inappropriate expression of genes determining reproductive traits as well as in the increased rate of aneuploid germ
cells related to prenatal and perinatal mortality.
CITATIONS(14):
1.
Effects of 5-azacytidine on lymphocyte-metaphases of Creole cows carrying the rob(1;29) R. Artigas, W. Iriarte, A. Iriarte, M. de Bethencourt, S. Llambí, A. Postiglioni Research in Veterinary Science
Chromosome Instability in a Calf with Amelia of Thoracic Limbs I. Szczerbal, T. Stefaniak, A. Dubiel, J. Siembieda, W. Nizanski, M. Switonski Veterinary Pathology
Molecular approach of the fragile chromosomal region Xq31-34 in cattle (Bos taurus) by microdissection and DOP-PCR S. Llambí, M.V. Arruga Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Identification of chromosome instability in Japanese quail (Coturnix japonica) E. Wójcik, K. Andraszek, E. Smalec, S. Knaga, A. Witkowski British Poultry Science
Analysis of chromatin instability of somatic cells in sheep Ewa Wójcik, Małgorzata Szostek, Elżbieta Horoszewicz, Emilia Kot, Sałuch Sebastian, Elżbieta Smalec, J. Plaizier Canadian Journal of Animal Science
Heterosome X premutation structural changes associated with fertility of Romanov sheep Barbara Danielak-Czech, Anna Kozubska-Sobocińska, Marek Babicz, Barbara Rejduch Annales UMCS, Zootechnica
Breeding and Economic Aspects of Cytogenetic Screening Studies of Pigs Qualified for Reproduction Barbara Danielak-Czech, Anna Kozubska-Sobocińska, Grzegorz Smołucha, Marek Babicz Animals
Chromosomal Instability at Fragile Sites in Blue Foxes, Silver Foxes, and their Interspecific Hybrids Marta Kuchta-Gładysz, Ewa Wójcik, Anna Grzesiakowska, Katarzyna Rymuza, Olga Szeleszczuk Animals
Effect of Selected Micro- and Macroelements and Vitamins on the Genome Stability of Bovine Embryo Transfer Recipients following In Vitro Fertilization Ewa Wójcik, Katarzyna Kępka, Mateusz Skup Animals
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