ORIGINAL PAPER
Mutagen-induced chromosome instability in farm animals
 
 
 
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Department of Immuno- and Cytogenetics, National Research Institute of Animal Production, Krakowska 1, 32-083 Balice, Poland
 
 
Publication date: 2004-04-09
 
 
Corresponding author
B. Danielak-Czech   

Department of Immuno- and Cytogenetics, National Research Institute of Animal Production, Krakowska 1, 32-083 Balice, Poland
 
 
J. Anim. Feed Sci. 2004;13(2):257-267
 
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ABSTRACT
The frequencies of spontaneous and in vitro mutagen-induced unstable chromosomal lesions were compared in the groups of subfertile cows, ewes and sows (test groups) as well as the animals without any reproductive disturbances (control groups). The mean percentage of 5-azacytidine- and bromodeoxyuridine-induced defects differed statistically between the test and control groups (P≤0.01 in cattle, P≤0.05 in sheep and pigs). In the groups of animals with reproductive problems the number of defects observed in some chromosomes exceeded the expected values (calculated according to the relative chromosome length), but only in the case of X chromosome differed at the level of statistical significance. Moreover, the groups of cows analysed differed significantly as regards the number of chromatid breaks/gaps at the Xq2.4 and Xq3.1 fragile sites. The excessive chromosome instability in subfertile farm animals, particularly the X-specific loci, may result in inappropriate expression of genes determining reproductive traits as well as in the increased rate of aneuploid germ cells related to prenatal and perinatal mortality.
 
CITATIONS (14):
1.
Effects of 5-azacytidine on lymphocyte-metaphases of Creole cows carrying the rob(1;29)
R. Artigas, W. Iriarte, A. Iriarte, M. de Bethencourt, S. Llambí, A. Postiglioni
Research in Veterinary Science
 
2.
Chromosome Instability in a Calf with Amelia of Thoracic Limbs
I. Szczerbal, T. Stefaniak, A. Dubiel, J. Siembieda, W. Nizanski, M. Switonski
Veterinary Pathology
 
3.
Molecular approach of the fragile chromosomal region Xq31-34 in cattle (Bos taurus) by microdissection and DOP-PCR
S. Llambí, M.V. Arruga
Arquivo Brasileiro de Medicina Veterinária e Zootecnia
 
4.
Assessment of chromosome instability in geese (Anser anser)
Ewa Wójcik, Elżbieta Smalec
Canadian Journal of Animal Science
 
5.
Identification of chromosome instability in Japanese quail (Coturnix japonica)
E. Wójcik, K. Andraszek, E. Smalec, S. Knaga, A. Witkowski
British Poultry Science
 
6.
A new case of reciprocal translocation t(10;13)(q16;q21) diagnosed in an AI boar
Barbara Danielak-Czech, Ewa Słota
Journal of Applied Genetics
 
7.
Analysis of chromatin instability of somatic cells in sheep
Ewa Wójcik, Małgorzata Szostek, Elżbieta Horoszewicz, Emilia Kot, Sałuch Sebastian, Elżbieta Smalec, J. Plaizier
Canadian Journal of Animal Science
 
8.
Assessment of genome stability in various breeds of cattle
Ewa Wójcik, Małgorzata Szostek, Juan Loor
PLOS ONE
 
9.
Heterosome X premutation structural changes associated with fertility of Romanov sheep
Barbara Danielak-Czech, Anna Kozubska-Sobocińska, Marek Babicz, Barbara Rejduch
Annales UMCS, Zootechnica
 
10.
Assessment of chromosome stability in boars
Ewa Wójcik, Agnieszka Sokół, Robert Sobol
PLOS ONE
 
11.
Breeding and Economic Aspects of Cytogenetic Screening Studies of Pigs Qualified for Reproduction
Barbara Danielak-Czech, Anna Kozubska-Sobocińska, Grzegorz Smołucha, Marek Babicz
Animals
 
12.
Chromosomal Instability at Fragile Sites in Blue Foxes, Silver Foxes, and their Interspecific Hybrids
Marta Kuchta-Gładysz, Ewa Wójcik, Anna Grzesiakowska, Katarzyna Rymuza, Olga Szeleszczuk
Animals
 
13.
Effect of Selected Micro- and Macroelements and Vitamins on the Genome Stability of Bovine Embryo Transfer Recipients following In Vitro Fertilization
Ewa Wójcik, Katarzyna Kępka, Mateusz Skup
Animals
 
14.
Identification of Genomic Instability in Cows Infected with BVD Virus
Katarzyna Kępka, Ewa Wójcik, Anna Wysokińska
Animals
 
ISSN:1230-1388
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