Preliminary results on exogenous ghrelin
administration  via  stomach tube influence on the crypt
cell proliferation in the small intestine mucosa
of neonatal piglets

M. Słupecka; J. Woliński

doi:10.22358/jafs/66800/2007

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ORIGINAL PAPER

Preliminary results on exogenous ghrelin administration via stomach tube influence on the crypt cell proliferation in the small intestine mucosa of neonatal piglets

M. Słupecka ¹

J. Woliński ¹

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The Kielanowski Institute of Animal Physiology and Nutrition, Department of Gastrointestinal Physiology, Polish Academy of Sciences, 05-110 Jabłonna, Poland

Publication date: 2007-09-06

Corresponding author

M. Słupecka

The Kielanowski Institute of Animal Physiology and Nutrition, Department of Gastrointestinal Physiology, Polish Academy of Sciences, 05-110 Jabłonna, Poland

J. Anim. Feed Sci. 2007;16(3):445-451

DOI: https://doi.org/10.22358/jafs/66800/2007

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Citations (2)

KEYWORDS

ghrelin

proliferation

small intestine

piglets

ABSTRACT

The aim of this study was to investigate the exogenous ghrelin effect on proliferation in the small intestinal mucosa, body and organs weight of neonatal piglets. Four groups (n=6) of pig neonates were examined: sow reared (C7SR), fed with milk formula (C7), fed with milk formula + ghrelin administrated via stomach tube in the dose of: 7.5 μg/kg body weight (BW) (G7.5) and 15 μg/kg BW (G15). Milk formula feeding (C7) strongly decreased mitotic rate in all parts of jejunum as compared to C7SR. Ghrelin treatment (G7.5) had a pro mitotic effect on the middle part of the small intestine (P<0.0001) as compared to C7. G15 treatment strongly increased the mitotic activity as compared to C7 (P<0.0001) and C7SR (P<0.0001). Unlike other forms of treatment in G15 mitotic activity was constant along all parts of small intestine. Moreover, ghrelin treatment decreased BW and increased stomach weight. In conclusion, exogenous ghrelin administrated in the dose of 15 μg/kg BW for 6 days resulted in the increase of the crypt cell proliferation in the small intestine mucosa of neonatal piglets.

CITATIONS (2):

Crypt fission contributes to postnatal epithelial growth of the small intestine in pigs
M. Słupecka, J. Woliński, S.G. Pierzynowski
Livestock Science

CrossRef

Effect of in ovo ghrelin administration on hatching results and post-hatching performance of broiler chickens
A. Lotfi, H. Aghdam Shahryar, H. Kaiya
Livestock Science

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