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ORIGINAL PAPER
Regulation of Nod-like receptor expression in the liver of ewes
during early pregnancy
1
Hebei University of Engineering, School of Life Sciences and Food Engineering, No. 19 Taiji Road, Handan 056038, China
Publication date: 2023-04-20
J. Anim. Feed Sci. 2023;32(3):267-279
KEYWORDS
TOPICS
ABSTRACT
Multiple factors are involved in the regulation of maternal-foetal
tolerance, and nucleotide-binding and oligomerisation domain (NOD)-like
receptors (NLRs) were shown to play roles in innate immune signalling
pathways. The objective of this study was to investigate the effects of early
pregnancy on the expression of NLRs in the liver of ewes. Livers from ewes
were collected on day 16 of the oestrous cycle, and days 13, 16 and 25 of
gestation (n = 6 for each group). Real-time quantitative PCR, Western blot
and immunohistochemical analysis were used to analyse mRNA and protein
expression of NLRs, including NOD1, NOD2, major histocompatibility complex
class II transactivator (CIITA), neuronal apoptosis inhibitor protein (NAIP), NLR
family, pyrin domain-containing 1 (NLRP1), NLRP3 and NACHT, LRR and PYD
domains-containing protein 7 (NLRP7). The data showed that NOD1, CIITA,
NLRP1, NLRP3 and NLRP7 were upregulated in maternal liver on days 13 to
25 of pregnancy, and NOD2 expression was upregulated on days 13 and 16
of pregnancy, but downregulated on day 25 of pregnancy. In addition, NOD2
and NLRP7 proteins were located in the endothelial cells of the proper hepatic
arteries and portal veins, and in hepatocytes. NAIP expression was the highest
at day 16 of pregnancy. In conclusion, this study reported for the first time that
early pregnancy modulated the expression of NLRs, suggesting that NLRs were
involved in the regulation of maternal hepatic immune functions during early
pregnancy in sheep.
FUNDING
This work was supported by the grants from
the Natural Science Foundation of Hebei Province,
China (C2022402038), and Hebei Science and
Technology Agency, China (22326602D).
CONFLICT OF INTEREST
The Authors declare that there is no conflict of
interest.
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