Understanding host susceptibility and resistance to Haemonchus contortus is crucial for developing effective management strategies in goat breeding. This study aimed to evaluate the susceptibility and resistance of male and female goats to H. contortus infections and to assess the intra- and inter-breed variability. The research, conducted in North Sumatra Province, Indonesia, involved 45 goats (22 females and 23 males, aged 4 to 6 months) categorised into five groups: A – Kacang goats (100% Kacang), B – crossbred (genetic composition of 50% Kacang and 50% Boer), C – Boer goats (100% Boer), D – crossbred (genetic composition of 25% Kacang and 75% Boer), E – crossbred (genetic composition of 75% Kacang and 25% Boer). The study employed a two-step process of analysing infection and monitoring hatching and infection of H. contortus larvae. Worm egg count, packed cell volume, total plasma protein, and body weight were measured over a 10-week period. Boer goats (group C) and their crossbreds (groups B, D, and E) demonstrated higher resistance to H. contortus compared to Kacang goats (group A). Male goats exhibited greater resistance, with slower worm egg development and less severe anaemia compared to females. Variability in resistance was observed within breeds, highlighting the importance of individual genetic factors. In conclusion, Boer goats and their crossbreds showed immunity to H. contortus infection, with male goats demonstrating enhanced resistance compared to females. These findings underscore the importance of genetic factors in modulating resistance and sustainable solutions for parasite management and emphasise the importance of decreasing treatment expenditures to improve goat health and productivity.