REVIEW PAPER
The role and molecular mechanisms of copper in regulating
animal lipid metabolism
1
Shandong Agricultural University, College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs,
Key Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-constructions by Ministry and Province),
271017 Tai’an, China
2
Sichuan Agricultural University, Institute of Animal Nutrition, Key Laboratory of Animal Disease-resistant,
611130 Chengdu, China
3
Research Center of Guangdong Haid Group Co., Ltd., 511400 Guangzhou, China
These authors had equal contribution to this work
Publication date: 2024-08-23
Corresponding author
Y. Li
Shandong Agricultural University, College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Key Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-constructions by Ministry and Province), 271017 Tai’an, China
Shandong Agricultural University, College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Key Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-constructions by Ministry and Province), 271017 Tai’an, China
KEYWORDS
TOPICS
ABSTRACT
Copper serves as a crucial nutrient in animal organisms, acting
as a cofactor in metabolic processes and facilitating enzyme formation.
Research indicates that high copper levels can enhance animal production
performance. However, excessive copper intake can lead to its accumulation,
causing metabolic disruptions linked to various diseases. Moreover, copper
supplementation can effectively reduce lipid synthesis, especially cholesterol
and triglycerides, while enhancing fat oxidation and breakdown by regulating
the activity of ATPase copper transporting beta (ATP7B), cyclic adenosine
monophosphate (cAMP) levels and endoplasmic reticulum stress, thereby
decreasing lipid accumulation in vivo. Additionally, copper deficiency in humans
has been closely associated with diseases characterised by fat accumulation.
Thus, this article comprehensively outlines the intricate interplay between copper
and lipid metabolism, elucidating potential underlying mechanisms.
FUNDING
This research was supported by the National Key Research and Development Program of China (2023YFD1300803), the Natural Science Foundation of Shandong Province (ZR2022QC084) and the National Natural Science Foundation of China (32302784).
CONFLICT OF INTEREST
The Authors declare that there is no conflict of interest.
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