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ORIGINAL PAPER
Time-dependent effect of inflammation on the gene expression
of pro-inflammatory cytokines and their receptors at the different
levels of the somatotropic axis in ewe
1
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Department of Genetic Engineering,
Instytucka 3, 05-110 Jabłonna, Poland
2
University of Agriculture in Krakow, Faculty of Animal Sciences, Department of Nutrition and Animal Biotechnology, and Fisheries,
31-120 Krakow, Poland
Publication date: 2023-11-30
Corresponding author
M. Wójcik
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Department of Genetic Engineering, Instytucka 3, 05-110 Jabłonna, Poland
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Department of Genetic Engineering, Instytucka 3, 05-110 Jabłonna, Poland
J. Anim. Feed Sci. 2023;32(4):400-412
KEYWORDS
TOPICS
ABSTRACT
Pituitary-hypothalamic-somatotropic (HPS) axis plays a key
regulatory role in the metabolic and physiological processes in mammals. It is
considered that inflammatory mediators such as proinflammatory cytokines,
whose receptors are widespread at the different levels of the HPS axis, may
be responsible for disturbing this axis activity. Our study was carried out to
determine the effect of lipopolysaccharide (LPS)-induced inflammation on the
expression of genes encoding pro-inflammatory cytokines and their receptors
in the organs belonging to the HPS axis. In vivo studies were carried out on
ewes (n = 36) divided randomly into 3 time-dependent groups (n = 12; each).
Each time group was divided into two subgroups: control (saline-treated; n = 6)
and intravenously treated with LPS (400 ng/kg; n = 6). Animals were euthanized
1.5 h, 3 h, or 9 h after LPS injection; and the fragments of the dorsomedial
hypothalamus and mediobasal hypothalamus, anterior pituitary, and liver were
collected. The relative gene expression encoding IL1B, IL1R1, IL1R2, IL6,
IL6R, IL6ST, TNF, TNFRSF1A, and TNFRSF1B was determined with real-time
PCR. Our experiment showed that LPS-induced inflammation modulates the
gene expression of pro-inflammatory cytokines such as IL1B, IL6, and TNF and
their corresponding receptor at the different levels of the HPS axis in sheep
at the time-dependent manner. Because these cytokines are known as potent
modulators of the secretion of hormones and neurohormones, the paracrine
action of these locally synthesized cytokines may disturb the activity of the HPS
axis; however, it requires further deep-in research.
FUNDING
This work was supported by the funds granted
by the National Science Centre, Poland, PRELUDIUM
project with registration number: 2017/25/N/
NZ9/01473.
CONFLICT OF INTEREST
The Authors declare that there is no conflict of
interest.
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