REVIEW PAPER
Towards a mechanistic model of amino acid uptake
and metabolism by the mammary gland of the
lactating dairy cow: A literature review
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1
Centre for Dairy Research, Department of Agriculture,
The University of Reading,
Earley Gate, PO Box 236, Reading, RG6 6AT, UK
2
Department of Animal and Poultry Science,
University of Guelph,
Guelph, ON. N1G2W1, Canada
Publication date: 1998-04-08
J. Anim. Feed Sci. 1998;7(2):105-129
KEYWORDS
ABSTRACT
A review is given of information available to produce a dynamic mechanistic model of amino
acid uptake and subsequent intracellular metabolism including milk and tissue protein synthesis
within the lactating bovine mammary gland. To be a truly mechanistic representation of actual biology the model must address each AA individually, uptake via transporters must be described bidirectionally as has been observed in vitro and in vivo, and the requirements for all mammary origin
milk proteins including α-lactalbumin and β-lactoglobulin must be addressed. A conceptual framework for such a model is advanced.
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